Nafamostat mesylate is a protease inhibitor useful in the treatment of acute pancreatitis. It has anticomplement,
anticoagulant, antikallikrein and other activities, and thus may have additional
utility in the treatment of autoimmune diseases and disseminated intravascular coagulation.
화학적 성질
Tan to pale orange solid
생물학적 활성
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
Synthesis
By p-guanidinobenzoic acid hydrochloride, 6-amidino groups-beta naphthal, 4,5-dicyano imidazole, methylene dichloride mix, 0-5 ℃ is stirred 1 hour, then improve temperature to 18-22 ℃, insulation reaction 8-12h, filters washed with dichloromethane, gained solid is 2 with methylsulfonic acid adjust pH, obtains nafamostat mesylate.
