Daptomycin manufacturers and suppliers

Daptomycin suppliers

Properties

Melting point:: 202-204?C

Boiling point:: 2078.2±65.0 °C(Predicted)

Density: 1.45±0.1 g/cm3(Predicted)

Flash point:: 87℃

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: methanol: soluble5mg/mL

pka: 4.00±0.10(Predicted)

form: powder

color: colorless to faint yellow

λmax: 260nm(EtOH)(lit.)

Merck: 14,2823

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

InChIKey: DOAKLVKFURWEDJ-RWDRXURGSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P280-P302+P352-P362+P364

WGK Germany: 3

RTECS: HB5626000

HS Code: 29419090

Toxicity: LD50 i.v. in mice: 600 mg/kg (Debono)

Use

Healthy volunteers were administrated (intravenous injection) of six different doses in the range of 0.5~6.0 mg/kg and 1.0 mg/kg 14C marked daptomycin, the results showed that daptomycin has a relatively long T1/2 in vivo (T1/2 = 6~8 h), a relatively small volume of distribution (V = 0.1~0.2 L/kg), and a renal clearance CLr of 0.17~0.2 ml/(min?kg). Daptomycin is mainly presented in the blood in the form of non-metabolized original drug with kidney as the major metabolic organ. About 78% of daptomycin is excreted in the urine. There are metabolites of daptomycin presented in the urine. The distribution pattern of daptomycin in the body is not fully understood. Patients of septicemia and endocarditis needs to subject to intravenous administration of daptomycin at a dose of 3mg/kg in every 12 h. Compared with healthy volunteers, people in daptomycin group had a average peak blood concentration (cmax): 35.45, which is lower than in healthy people. They also had an increased steady-state volume of distribution (Vss = 0.21) and a 22% increased clearance rate (CL).

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