Pleuromulin manufacturers and suppliers

Pleuromulin suppliers

Pleuromulin

CAS:: 125-65-5

MF:: C22H34O5

MW:: 378.5

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Properties

Melting point:: 170-1710C

alpha: D24 +20° (c = 3 in abs ethanol)

Boiling point:: 482.8±45.0 °C(Predicted)

Density: 1.15±0.1 g/cm3(Predicted)

storage temp.: -20°C Freezer

solubility: DMSO: >10mg/mL (warmed)

form: powder

pka: 12.91±0.10(Predicted)

color: white to beige

optical activity: [α]/D +30 to +40° (c=1; CH2Cl2)

InChIKey: YSBXUHAJXRCCET-BKUNHTPHSA-N

Safety Information

Symbol(GHS): GHS07,GHS09

Signal word: Warning

Hazard statements: H302-H410

Precautionary statements: P264-P270-P273-P301+P312-P391-P501

WGK Germany: 3

RTECS: MC5408000

Toxicity: LD50 in mice: >60 mg/kg (Kavanagh, 1952)

Use

Pleuromulin is Crystalline Solid Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin. Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.

You can find Pleuromulin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.