LY-2584702 (tosylate salt)
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- $32 - $1750
- Product name: LY-2584702 (tosylate salt)
- CAS: 1082949-68-5
- MF: C28H27F4N7O3S
- MW: 617.62
- EINECS:
- MDL Number:MFCD29054739
- Synonyms:4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate (1:1);LY-2584702 (tosylate salt);LY2584702 Tosylate;4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate;LY-2584702;LY 2584702;LYS6K2;LYS6K2;LYS6K2(LY2584702) tosylate salt;CS-2145
24 prices
Selected condition：
Brand
- AK Scientific
- Apolloscientific
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3528DG
- Product descriptionLY-2584702(tosylatesalt)
- Packaging50mg
- Price$735
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0229
- Product descriptionLY2584702tosylate
- Packaging1mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0229
- Product descriptionLY2584702tosylate
- Packaging5mg
- Price$131
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0229
- Product descriptionLY2584702tosylate
- Packaging10mg
- Price$203
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2464
- Product descriptionLY2584702tosylate 98%
- Packaging10mg
- Price$137.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2464
- Product descriptionLY2584702tosylate 98%
- Packaging50mg
- Price$412.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15320
- Product descriptionLY2584702 (tosylate) ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15320
- Product descriptionLY2584702 (tosylate) ≥98%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15320
- Product descriptionLY2584702 (tosylate) ≥98%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15320
- Product descriptionLY2584702 (tosylate) ≥98%
- Packaging25mg
- Price$420
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM151839
- Product description4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine4-methylbenzenesulfonate 98%
- Packaging100mg
- Price$367
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3597
- Product descriptionLY-2584702tosylatesalt 98.12%
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3597
- Product descriptionLY-2584702tosylatesalt 98.12%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3597
- Product descriptionLY-2584702tosylatesalt 98.12%
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3597
- Product descriptionLY-2584702tosylatesalt 98.12%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004631
- Product descriptionLY-2584702tosylatesalt 98+%
- Packaging50mg
- Price$409
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3528DG | LY-2584702(tosylatesalt) | 50mg | $735 | 2021-12-16 | Buy |
| Apolloscientific | BISN0229 | LY2584702tosylate | 1mg | $73 | 2021-12-16 | Buy |
| Apolloscientific | BISN0229 | LY2584702tosylate | 5mg | $131 | 2021-12-16 | Buy |
| Apolloscientific | BISN0229 | LY2584702tosylate | 10mg | $203 | 2021-12-16 | Buy |
| Axon Medchem | Axon2464 | LY2584702tosylate 98% | 10mg | $137.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2464 | LY2584702tosylate 98% | 50mg | $412.5 | 2021-12-16 | Buy |
| Cayman Chemical | 15320 | LY2584702 (tosylate) ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15320 | LY2584702 (tosylate) ≥98% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 15320 | LY2584702 (tosylate) ≥98% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 15320 | LY2584702 (tosylate) ≥98% | 25mg | $420 | 2024-03-01 | Buy |
| Chemenu | CM151839 | 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine4-methylbenzenesulfonate 98% | 100mg | $367 | 2021-12-16 | Buy |
| ChemScene | CS-3597 | LY-2584702tosylatesalt 98.12% | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-3597 | LY-2584702tosylatesalt 98.12% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-3597 | LY-2584702tosylatesalt 98.12% | 50mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-3597 | LY-2584702tosylatesalt 98.12% | 100mg | $650 | 2021-12-16 | Buy |
| Crysdot | CD31004631 | LY-2584702tosylatesalt 98+% | 50mg | $409 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO:12.55(Max Conc. mg/mL);20.31(Max Conc. mM)
form :A crystalline solid
solubility :DMSO:12.55(Max Conc. mg/mL);20.31(Max Conc. mM)
form :A crystalline solid
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
p70 Ribosomal S6 kinase (p70S6K) is a serine/threonine kinase that is activated by insulin and growth factors through PI3K and mTORC1 signaling pathways. LY2584702 is a selective, cell-permeable p70S6K inhibitor (IC50 = 4 nM). It blocks phosphorylation of p70S6K in primary rat hepatocytes without affecting the phosphorylation of other signaling kinases, including GSK-3β and ERK1/2. LY2584702 inhibits phosphorylation of p70S6K in HCT116 colon cancer cells (IC50 = 0.1-0.24 μM in vitro) and demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. It also reverses the effects of mTORC1 hyperactivation on triglyceride metabolism in human hepatoma cells. LY2584702, alone or in combination with the mTOR inhibitor everolimus , has been evaluated in clinical trials against solid tumors.Related product price
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