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ChemicalBook >> CAS DataBase List >> DDD85646

DDD85646

DDD85646 price.
  • $97 - $672
  • Product name: DDD85646
  • CAS: 1215010-55-1
  • MF: C21H24Cl2N6O2S
  • MW: 495.43
  • EINECS:
  • MDL Number:
  • Synonyms:DDD85646;DDD 85646 (DDD85646);Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;DDD85646 Hydrochloride;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
Price7 Properties Safety Information Description
7 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
  • Usbiological
Package
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number2777DF
  • Product description2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide
  • Packaging1mg
  • Price$206
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2777DF
  • Product description2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide
  • Packaging5mg
  • Price$553
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13839
  • Product descriptionDDD85646 ≥98%
  • Packaging1mg
  • Price$97
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13839
  • Product descriptionDDD85646 ≥98%
  • Packaging5mg
  • Price$410
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13839
  • Product descriptionDDD85646 ≥98%
  • Packaging10mg
  • Price$672
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberD195323
  • Product descriptionDDD85646
  • Packaging2.5mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number445831
  • Product descriptionDDD85646
  • Packaging1mg
  • Price$410
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2777DF 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide 1mg $206 2021-12-16 Buy
AK Scientific 2777DF 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide 5mg $553 2021-12-16 Buy
Cayman Chemical 13839 DDD85646 ≥98% 1mg $97 2024-03-01 Buy
Cayman Chemical 13839 DDD85646 ≥98% 5mg $410 2024-03-01 Buy
Cayman Chemical 13839 DDD85646 ≥98% 10mg $672 2024-03-01 Buy
TRC D195323 DDD85646 2.5mg $265 2021-12-16 Buy
Usbiological 445831 DDD85646 1mg $410 2021-12-16 Buy

Properties

Melting point :>215°C (dec.)
Boiling point :684.3±65.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly, Heated), Methanol (Slightly)
form :Solid
pka :7.04±0.50(Predicted)
color :Off-White to Yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai Rechem science Co., Ltd. Shanghai Chaolan Chemical Technology Center Shanghai Hongye Biotechnology Co. Ltd