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| | (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Basic information |
| Product Name: | (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide | | Synonyms: | LABOTEST-BB LT00233112;(1,3-DIOXOLAN-2-YLMETHYL)TRIPHENYLPHOSPHONIUM BROMIDE;(1,3-DIOXOLANE-2-YL METHYL) TRIPHENYL PHOSPHONIUM BROMIDE;TRIPHENYL-1,3-DIOXOLAN-2-YLMETHYL-PHOSPHONIUM BROMIDE;2-(1,3)-DIOXOLANE-2-YL-METHYLTRIPHENYLPHOSPHONIUM BROMIDE;(1,3-DIOXOLAN-2-YLMETHYL)TRIPHENYLPHOSPHONIUM BROMIDE 98%;(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98 %;Phosphonium, (1,3-dioxolan-2-ylmethyl)triphenyl-, bromide | | CAS: | 52509-14-5 | | MF: | C22H22BrO2P | | MW: | 429.29 | | EINECS: | 257-977-3 | | Product Categories: | Dioxanes & Dioxolanes;Dioxolanes;Phosphonium Compounds;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction;Wittig Reaction;C-C Bond Formation;Olefination;Wittig Reagents | | Mol File: | 52509-14-5.mol |  |
| | (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Chemical Properties |
| Melting point | 193-195 °C(lit.) | | storage temp. | Store below +30°C. | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Powder or Crystals | | color | White to light brown | | Water Solubility | Soluble in water (20°C). | | Sensitive | Hygroscopic | | InChIKey | FRHRVQQUICVJDG-UHFFFAOYSA-M | | CAS DataBase Reference | 52509-14-5(CAS DataBase Reference) |
| | (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Usage And Synthesis |
| Chemical Properties | white to light brown granular powder | | Uses | Reactant for:
- Preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione
- Microwave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase II
- Preparation of fluorinated spirobenzofuran piperidines as s1 receptor ligands
- Synthesis and antitumor agents
- Regio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization
| | Uses | (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens. | | Purification Methods | Wash the crystals with Et2O, dry them in a vacuum and recrystallise them from CH2Cl2/dry Et2O to give prisms m 172-174o, which is raised to 191.5-193o on drying at 56o/0.5mm. [Cresp et al. J Chem Soc, Perkin Trans 1 37 1974.] |
| | (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide Preparation Products And Raw materials |
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