粪卟啉二盐酸盐
| 中文名称 | 粪卟啉二盐酸盐 |
|---|---|
| 中文同义词 | 粪卟啉III二盐酸盐;酚卟啉二盐酸盐;粪卟啉 Ⅲ;化合物 T19247;酚卟啉III;COPROPORPHYRIN III (ZINCPHYRIN) |
| 英文名称 | COPROPORPHYRIN III DIHYDROCHLORIDE |
| 英文同义词 | COPROPORPHYRIN III DIHYDROCHLORIDE;3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,7,12, 18-TETRAPROPIONIC ACID DIHYDROCHLORIDE;coproporphyriniii2HCl;Coproporphyrin Ⅲ dihydrochloride;3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrapropanoic acid;Coproporphyrin dihydrochloride;2,7,12,18-Tetramethyl-21H,23H-porphyrin-3,8,13,17-tetrapropionic acid;CoproporphyrinIII Dihyrochloride |
| CAS号 | 14643-66-4 |
| 分子式 | C36H38N4O8 |
| 分子量 | 654.71 |
| EINECS号 | |
| 相关类别 | porphine (porphyrin) ligand;Natural Porphyrins and Derivitives;Porphyrins |
| Mol文件 | 14643-66-4.mol |
| 结构式 |  |
粪卟啉二盐酸盐 性质
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
|---|---|
| 溶解度 | DMSO（轻微，超声处理），甲醇（轻微） |
| 形态 | 晶体 |
| 沸点 | 1258.0±65.0 °C(Predicted) |
| 密度 | 1.366±0.06 g/cm3(Predicted) |
| 颜色 | 紫色的 |
| 稳定性 | 吸湿性 |
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Human Endogenous Metabolite
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Coproporphyrin III methyl ester is repeatedly isolated in considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease. Primary cultures of chick embryo hepatocytes have been used to study the mechanism by which chemicals cause accumulation of intermediates of the heme synthetic pathway. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), addition of insulin causes a striking increase in accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolishes the uroporphyrin I accumulation and increases coproporphyrin III.
Urinary DMA and porphyrin profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control.