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| | BRD4770 Basic information |
| Product Name: | BRD4770 | | Synonyms: | BRD4770;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester;CS-1814;Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate;BRD-4770; BRD 4770;Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate | | CAS: | 1374601-40-7 | | MF: | C25H23N3O3 | | MW: | 413.47 | | EINECS: | 802-776-3 | | Product Categories: | Inhibitors | | Mol File: | 1374601-40-7.mol |  |
| | BRD4770 Chemical Properties |
| density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | pka | 12.12±0.43(Predicted) | | form | powder | | color | white to beige | | CAS DataBase Reference | 1374601-40-7 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | BRD4770 Usage And Synthesis |
| Uses | BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical] | | Definition | ChEBI: 2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles. | | Biochem/physiol Actions | BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth. |
| | BRD4770 Preparation Products And Raw materials |
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