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| | Leniolisib Basic information |
| Product Name: | Leniolisib | | Synonyms: | Leniolisib;CDZ173;CDZ-173;CDZ 173;CS-2818;leniolisib(CDZ 173);CDZ 173;1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-;(S)-1-(3-((6-(6-Methoxy-5-(trifluoromethyl)pyridin-3-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)propan-1-one;inhibit,Inhibitor,Phosphoinositide 3-kinase,Leniolisib,PI3K,CDZ-173,CDZ 173 | | CAS: | 1354690-24-6 | | MF: | C21H25F3N6O2 | | MW: | 450.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1354690-24-6.mol |  |
| | Leniolisib Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:71.67(Max Conc. mg/mL);159.09(Max Conc. mM)
Ethanol:16.5(Max Conc. mg/mL);36.63(Max Conc. mM) | | form | A crystalline solid |
| | Leniolisib Usage And Synthesis |
| Biological Activity | Leniolisib (CDZ 173) is a potent and selective PI3Kδ inhibitor with IC50s of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. | | target | | Target | Value | PI3Kδ
(Cell-free assay) | 0.011 μM | PI3Kα
(Cell-free assay) | 0.244 μM | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PI3Kβ
(Cell-free assay) 0.424 μM | DNA-PK
() | 0.88 μM | DNA-PK
(Cell-free assay) | 0.88 μM |
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| | Leniolisib Preparation Products And Raw materials |
| Raw materials | 1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)--->1-Pyrrolidinecarboxylic acid, 3-[[5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]amino]-, 1,1-dimethylethyl ester, (3S)--->1-Pyrrolidinecarboxylic acid, 3-[(5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino]-, 1,1-dimethylethyl ester, (3S)--->6-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-->5-bromo-2-methoxy-3-(trifluoromethyl)pyridine-->2-Methoxy-3-(trifluoromethyl)pyridine-->(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine-->2-Chloro-3-(trifluoromethyl)pyridine-->Propionyl chloride |
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