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PCO371

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PCO371 Suppliers list
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139
Email: orders@jknbiochem.com
Products Intro: Product Name:PCO371
CAS:1613373-33-3
Purity:0.98 Package:10G:100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PCO371；2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-
CAS:1613373-33-3
Purity:98.00% Package:10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:PCO371
CAS:1613373-33-3
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:PCO371
CAS:1613373-33-3
Purity:0.98 Package:5mg，10mg，100mg，500mg，1g，5g，10g，more
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:PCO371
CAS:1613373-33-3
Purity:95% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
PCO371 Basic information
Product Name:PCO371
Synonyms:PCO371;CPD2050;2,4-Imidazolidinedione, 1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-;1-[3,5-Dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-2,4-imidazolidinedione;PCO371,PCO 371,inhibit,Inhibitor,THR,PCO-371,Thyroid Hormone Receptor;1-[3,5-Dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethylimidazolidine-2,4-dione
CAS:1613373-33-3
MF:C29H32F3N5O6S
MW:635.65
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Mol File:1613373-33-3.mol
PCO371 Structure
PCO371 Chemical Properties
density 1.47±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (196.65 mM)
pka8.39±0.10(Predicted)
InChIKeyLDZJFVOUPUFOHX-UHFFFAOYSA-N
SMILESC1(=O)N(C2=CC(C)=C(CCS(N3CCC4(N=C(C5=CC=C(OC(F)(F)F)C=C5)NC4=O)CC3)(=O)=O)C(C)=C2)C(C)(C)C(=O)N1
Safety Information
MSDS Information
PCO371 Usage And Synthesis
DescriptionPCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation[1].
Biological ActivityPCO371 selectively induces cAMP production in COS-7 cells expressing human PTH1R (EC50 = 2.4 μM) over COS-7 cells expressing human PTH2R (EC50 = > 100 μM). PCO371 (1 and 3 μM) induces calcium release from isolated fetal rat long bones. It increases lumbar spine and proximal femur bone mineral density (BMD), lumbar spine bone strength, serum levels of osteocalcin, and bone formation in the lumbar spine without affecting serum calcium levels in an ovariectomized (OVX) rat model of osteopenia when administered at a dose of 10 mg/kg per day. PCO371 (9 mg/kg) increases serum, but not urinary, calcium levels in a hypocalcemic thyroparathyroidectomized (TPTX) rat model of hypothyroidism.
PCO371 Preparation Products And Raw materials
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