|
|
| | 3-Bromopropylamine hydrobromide Basic information |
| | 3-Bromopropylamine hydrobromide Chemical Properties |
| Melting point | 171-172 °C(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | form | Powder or Chunks | | color | White to off-white | | Water Solubility | Soluble in water (50 mg/ml). | | Sensitive | Hygroscopic | | BRN | 3906418 | | InChI | InChI=1S/C3H8BrN.BrH/c4-2-1-3-5;/h1-3,5H2;1H | | InChIKey | PQIYSSSTRHVOBW-UHFFFAOYSA-N | | SMILES | C(CBr)CN.Br | | CAS DataBase Reference | 5003-71-4(CAS DataBase Reference) | | EPA Substance Registry System | 1-Propanamine, 3-bromo-, hydrobromide (5003-71-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | UH9925000 | | TSCA | Yes | | HS Code | 29211980 |
| | 3-Bromopropylamine hydrobromide Usage And Synthesis |
| Chemical Properties | white to off-white powder or chunks | | Uses | 3-Bromopropylamine hydrobromide is commonly used as a reagent to introduce propylamine group to the molecular skeleton. Some of the other reported applications include:
- Synthesis of photochemically and thermally reactive azobenzene rotaxane and indolocarbazole-containing [2]rotaxane.
- Synthesis of indenoisoquinoline based active topoisomerase I inhibitors as anticancer agents.
| | Uses | 3-Bromopropylamine hydrobromide is used as pharmaceutical raw materials and intermediates. Homotaurine is synthesized from 3-bromopropylamine hydrobromide. | | Synthesis | Add the mixture of 3-amino-1-propanol (1ml, 13.3mmol) and 48% HBr (10ml, 40mmol) into the round-bottomed flask and reflux for 15h. Water and HBr were then distilled from the mixture under vacuum. The mixture was further dried under vacuum through a KOH/CaCl column to give 3-Bromopropylamine hydrobromide (2.95 g, 100%) as a brown solid.
|
| | 3-Bromopropylamine hydrobromide Preparation Products And Raw materials |
|