GRGDSPK
中文名称 | GRGDSPK |
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中文同义词 | (2S)-6-AMINO-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[(2-AMINOACETYL)AMINO]-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]ACETYL]AMINO]-3-CARBOXYPROPANOYL]AMINO]-3-HYDROXYPROPANOYL]PYRROLIDINE-2-CARBONYL]AMINO]HEXANOIC ACID;抑制肽EMD 56574 |
英文名称 | GLY-ARG-GLY-ASP-SER-PRO-LYS |
英文同义词 | H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH;GRGDSPK;GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE;GLY-ARG-GLY-ASP-SER-PRO-LYS;GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE;glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine;EMD 56574;L-Lysine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl- |
CAS号 | 111119-28-9 |
分子式 | C28H49N11O11 |
分子量 | 715.76 |
EINECS号 | |
相关类别 | 多肽;对照品;标准品;peptide |
Mol文件 | 111119-28-9.mol |
结构式 |
GRGDSPK 性质
密度 | 1.59±0.1 g/cm3(Predicted) |
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储存条件 | -20°C |
酸度系数(pKa) | 3.60±0.21(Predicted) |
GRGDSPK (EMD 56574; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner as determined by measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats.
GRGDSPK (10, 50 μM; for 4 days) dramatically alteres bone morphology, with a disruption of osteoblast and mineralized matrix organization.
GRGDSPK (RGD; 250 μM), added to the medium, effectively blocks integrin-fibronectin binding and significantly increases the average size of wild-type cell aggregates.
When GRGDSPK (250 μM) is added, wild-type mesendodermal progenitors exhibits strongly reduced adhesion forces and work, indicating that the detachment parameters recorded are specific for fibronectin and that integrins expressed in mesendodermal progenitors are involved.
GRGDSPK (RGD-containing, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-mod-ified peptides impair the ability of sperm to fertilizebovine oocytes, illustrated by a reduction in cleavage in a dose-dependent manner.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-P0322 | GRGDSPK GRGDSPK | 111119-28-9 | 5mg | 3800元 |
2024/04/30 | HY-P0322 | GRGDSPK GRGDSPK | 111119-28-9 | 10mg | 6800元 |