- Amsacrine USP/EP/BP
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- $1.10 / 1g
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2021-07-02
- CAS:51264-14-3
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Amsacrine
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- $0.00 / 1KG
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2020-04-30
- CAS:51264-14-3
- Min. Order: 1KG
- Purity: 99.0%+
- Supply Ability: 800 tons
- Amsacrine
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- $9.80 / 1KG
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2020-01-10
- CAS:51264-14-3
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 20 tons
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| | Amsacrine Basic information |
| | Amsacrine Chemical Properties |
| Melting point | 230-240 °C | | Boiling point | 563.0±60.0 °C(Predicted) | | density | 1.2205 (rough estimate) | | refractive index | 1.6740 (estimate) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO | | form | Powder | | pka | 8.55±0.10(Predicted) | | CAS DataBase Reference | 51264-14-3 | | IARC | 2B (Vol. 76) 2000 |
| | Amsacrine Usage And Synthesis |
| Description | Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia
which has failed primary treatment or become resistant. Its clinical use, however, is
associated with significant neuro-, gastro- and hepatotoxicity. | | Originator | Auckland Cancer Chemotherapy Lab (New Zealand) | | Uses | Amsacrine (Amsidyl) is used as an Investigational drug. | | Uses | Antineoplastic. | | Uses | Amsacrine is a drug undergoing intensive trials for severe leukemia and lymphoma. It is a
cytotoxic drug that binds with DNA with expressed specificity to the adenosine–tyrosine
pair, thus inhibiting DNA synthesis. It has been suggested to be used for severe leukemia.
A synonym of this drug is amsidyl. | | Definition | ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity. | | Brand name | Amsidyl (Parke-Davis);Amsakrin. | | Synthesis | Amsacrine, 4-(9-acridinylamino)-3-methoxyphenyl-N-methansulfonamide
(30.6.11), is made by sulfonating 4-nitro-m-anisidine with methanesulfonyl chloride,
which forms a sulfonyl amide 30.6.9, and the nitro group is reduced to an amino group by
hydrogen, forming 4-amino-3-methoxyphenyl-N-methansulfonamide (30.6.10). Reacting
this with 9-chloroacridine gives amsacrine (30.6.11). 
| | references | [1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5. |
| | Amsacrine Preparation Products And Raw materials |
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