1189561-66-7
中文名称 | 1189561-66-7 |
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中文同义词 | BCL-2抑制剂((S)-GOSSYPOL ACETIC ACID);(S)-(+)-GOSSYPOL ACETIC ACID|||(S)-GOSSYPOL ACETIC ACID |
英文名称 | (S)-Gossypol (acetic acid) |
英文同义词 | (S)-Gossypol (acetic acid) |
CAS号 | 1189561-66-7 |
分子式 | C32H34O10 |
分子量 | 578.61 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 1189561-66-7.mol |
结构式 |
1189561-66-7 性质
储存条件 | Store at -20°C, protect from light, stored under nitrogen |
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溶解度 | DMSO:50mg/mL(86.41mM);水:< 0.1 mg/mL(不溶) |
Bcl-2
|
Bcl-xL
|
The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-15464D | (S)-Gossypol (acetic acid) | 5 mg | 875元 | |
2024/04/30 | HY-15464D | 1189561-66-7 (S)-Gossypol (acetic acid) | 1189561-66-7 | 10mg | 1400元 |