半胱胺酸蛋白酶蛋白-7抗体
| 中文名称 | 半胱胺酸蛋白酶蛋白-7抗体 |
|---|---|
| 中文同义词 | ANTI-CASPASE-7抗体;半胱胺酸蛋白酶蛋白-7抗体 |
| 英文名称 | Anti-Caspase-7 Antibody |
| 英文同义词 | ANTI-CASPASE-7;Anti-Caspase-7 Antibody |
| CAS号 | |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
半胱胺酸蛋白酶蛋白-7抗体 性质
Caspase-7 Rabbit monoclonal AntibodyRabbitRecombinant fragment within Human Caspase-7 aa 1-200.Mouse, Rat, HumanWB, IHC-P, Flow CytFlow Cytometry - Anti-Caspase-7 antibody [EPR22839-12] (ab255818)---Abcam
Flow cytometric analysis of 4% paraformaldehyde fixed, 90% methanol permeabilized C2C12 (mouse muscle) cells labeling Caspase-7 with ab255818 at 1/50 (Red) compared with a Rabbit monoclonal IgG (ab172730) / Black isotype control and an unlabeled control (cells without incubation with primary antibody and secondary antibody) (Blue). A Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.
Flow cytometric analysis of 4% paraformaldehyde fixed, 90% methanol permeabilized C2C12 (mouse muscle) cells labeling Caspase-7 with ab255818 at 1/50 (Red) compared with a Rabbit monoclonal IgG (ab172730) / Black isotype control and an unlabeled control (cells without incubation with primary antibody and secondary antibody) (Blue). A Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) at 1/2000 dilution was used as the secondary antibody.Caspase-7（CMH-1、Mch3、ICE-LAP3）被鉴定为凋亡的主要执行者。caspase-7 和 caspase-3一样，是一种半胱天冬酶效应子，负责裂解下游底物，如（ADP-核糖）聚合酶和 PARP 。在细胞凋亡期间，caspase-7 在 ASP23、Asp198 和 Asp206 位点通过蛋白水解过程由上游半胱天冬酶激活，从而产生成熟的亚基 。与 caspase-2 和 -3 相似，caspase-7 在识别序列 DEVD 后，优先裂解底物。