异冬谷酸
| 中文名称 | 异冬谷酸 |
|---|---|
| 中文同义词 | 盐酸索他洛尔-D6;N-乙酰基-L-天冬氨酰-L-谷氨酸;异冬谷酸;(S)-2-((S)-2-乙酰氨基-3-羧基丙酰胺基)戊二酸;SPAGLUMIC ACID/异冬谷酸 |
| 英文名称 | N-acetyl aspartyl-glutaMic acid |
| 英文同义词 | SPAGLUMIC ACID;NAAG;N-ACETYL-L-ASPARTYL-L-GLUTAMIC ACID;N-ACETYLASPARTYLGLUTAMIC ACID;N-ACETYL-ASP-GLU;N-ACETYL-ASP-GLU-OH;ALPHA-NAAG;AC-ASP-GLU |
| CAS号 | 3106-85-2 |
| 分子式 | C11H16N2O8 |
| 分子量 | 304.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 3106-85-2.mol |
| 结构式 |  |
异冬谷酸 性质
| 熔点 | 171-173 °C |
|---|---|
| 沸点 | 769.5±60.0 °C(Predicted) |
| 密度 | 1.472±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | H2O:50 mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.04±0.10(Predicted) |
| 颜色 | 白色 |
| 旋光性 (optical activity) | [α]22/D 34.5°, c = 1.1 in H2O(lit.) |
| 水溶解性 | Soluble to 100 mM in water |
| 稳定性 | 吸湿性 |
Spaglumic Acid (N-Acetylaspartylglutamic acid) 是一种在脑中以毫摩尔浓度存在的神经肽。
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Human Endogenous Metabolite
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Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca 2+ -dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.
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英文
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