SER-LEU-ILE-GLY-ARG-LEU-NH2
| 中文名称 | SER-LEU-ILE-GLY-ARG-LEU-NH2 |
|---|---|
| 中文同义词 | 蛋白酶激活的受体-2激活肽;激动剂肽-PAR-2 (1-6) AMIDE (MOUSE, RAT);SLIGRL-NH2 2TFA |
| 英文名称 | H-SER-LEU-ILE-GLY-ARG-LEU-NH2 |
| 英文同义词 | COAGULATION FACTOR II RECEPTOR-LIKE 1 (1-6) AMIDE (MOUSE, RAT);H-SER-LEU-ILE-GLY-ARG-LEU-NH2;H2N-SLIGRL-AMIDE;Ser-Leu-Ile-Gly-Arg-Leu-NH2;SLIGRL-NH2 Protease-Activated Receptor 2 (PAR2) Agonist;PAR2-AP, SLIGRL-NH2;Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt;ThroMbin Receptor-Like 1 (1-6) aMide (Mouse, rat), SLIGRLaMide, Proteinase Activated Receptor 2 (1-6) aMide (Mouse, rat), Coagulation Factor II Receptor-Like 1 (1-6) aMide (Mouse, rat) |
| CAS号 | 171436-38-7 |
| 分子式 | C29H56N10O7 |
| 分子量 | 656.82 |
| EINECS号 | |
| 相关类别 | 多肽;标准品;Proteinase-activated receptor (PAR);Peptide Receptors;peptide |
| Mol文件 | 171436-38-7.mol |
| 结构式 |  |
SER-LEU-ILE-GLY-ARG-LEU-NH2 性质
| 密度 | 1.34±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | DMSO（少许）、甲醇（少许）、水（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.04±0.10(Predicted) |
| 水溶解性 | Soluble to 1 mg/ml in water |
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) 是一种蛋白酶激活受体-2 (PAR-2) 激动剂。
PAR-2
SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH 2 causing a concentration-dependent relaxation with an EC 50 of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)].
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-P1308 | SER-LEU-ILE-GLY-ARG-LEU-NH2 SLIGRL-NH2 | 171436-38-7 | 1mg | 700元 |
| 2024/04/30 | HY-P1308 | SER-LEU-ILE-GLY-ARG-LEU-NH2 SLIGRL-NH2 | 171436-38-7 | 5mg | 1900元 |