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| | PHYSOSTIGMINE SALICYLATE Basic information |
| | PHYSOSTIGMINE SALICYLATE Chemical Properties |
| Melting point | 181-183 °C | | storage temp. | -20°C | | solubility | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml | | pka | pKa 1.96/8.08(H2O,t =15) (Uncertain) | | Merck | 7384 | | BRN | 3900576 | | InChIKey | HZOTZTANVBDFOF-DPKVYHSMNA-N | | SMILES | C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r| | | CAS DataBase Reference | 57-64-7(CAS DataBase Reference) | | EPA Substance Registry System | Physostigmine salicylate (57-64-7) |
| Hazard Codes | T+ | | Risk Statements | 26/28 | | Safety Statements | 25-45 | | RIDADR | UN 1544 6.1/PG 1 | | WGK Germany | 3 | | RTECS | TJ2450000 | | HazardClass | 6.1(a) | | PackingGroup | II | | HS Code | 2939800000 | | Toxicity | LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) |
| | PHYSOSTIGMINE SALICYLATE Usage And Synthesis |
| Chemical Properties | solid | | Uses | Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet | | Uses | cholinergic, anticholinesterase, miotic | | Definition | ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine. | | Brand name | Antilirium (Forest); Isopto Eserine (Alcon). | | General Description | The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions. | | General Description | Crystal form that turns red on exposure to heat or light. | | Reactivity Profile | Behaves as a weak acid in solution. | | Health Hazard | PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor. | | Fire Hazard | When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides. | | Safety Profile | Poison by ingestion,
subcutaneous, intramuscular, intravenous,
and intraperitoneal routes. Human systemic
effects: arrhythmias, nausea or vomiting.
Experimental reproductive effects. When
heated to decomposition it emits toxic
fumes of NOx See also
PHYSOSTIGMINE. |
| | PHYSOSTIGMINE SALICYLATE Preparation Products And Raw materials |
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