细胞穿透肽
| 中文名称 | 细胞穿透肽 |
|---|---|
| 中文同义词 | 细胞穿透肽 TRANSDERMAL PEPTIDE |
| 英文名称 | H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond) |
| 英文同义词 | H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH, (Disulfide bond);Transdermal Peptide (TD 1 peptide);TD 1 (peptide);Glycine, L-alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinyl-, cyclic (2→10)-disulfide (9CI);Transdermal Peptide Disulfide |
| CAS号 | 888486-23-5 |
| 分子式 | C40H64N14O16S2 |
| 分子量 | 1061.15 |
| EINECS号 | |
| 相关类别 | 多肽;美容肽;目录多肽 |
| Mol文件 | 888486-23-5.mol |
| 结构式 |  |
细胞穿透肽 性质
| 沸点 | 1728.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.57±0.10(Predicted) |
| 序列 | H-Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly-OH(Disulfide bond) |
In the presence of Transdermal Peptide Disulfide, because of the specific binding of Transdermal Peptide Disulfide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide Disulfide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide Disulfide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%