TCN-201
| 中文名称 | TCN-201 |
|---|---|
| 中文同义词 | 4-[[[(3-氯-4-氟苯基)磺酰基]氨基]甲基]苯甲酸 2-苯甲酰基酰肼;N-(4-(2-苯甲酰肼羰基)苄基)-3-氯-4-氟苯磺酰胺 |
| 英文名称 | 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide |
| 英文同义词 | 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide;TCN 201;N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonaMide;4-[[[(3-Chloro-4-fluorophenyl)sulfonyl]aMino]Methyl]benzoic Acid 2-Benzoylhydrazide;TCN 201-d5;TCN-201 N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4- fluorobenzenesulfonaMide;3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide;N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide |
| CAS号 | 852918-02-6 |
| 分子式 | C21H17ClFN3O4S |
| 分子量 | 461.89 |
| EINECS号 | |
| 相关类别 | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 852918-02-6.mol |
| 结构式 |  |
TCN-201 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶，5mg/mL（澄清溶液） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
pIC50: 6.8 (GluN1/GluN2A NMDA receptor)
TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC
50
s of 6.8 and <4.3, respectively.
TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.
TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.
TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.
TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.
TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.
TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 22-36/37/38 |
| 安全说明 | 26-36/37/39 |
| WGK Germany | 3 |