2'-去氧-2'-氟-2'-C-甲基胞苷
| 中文名称 | 2'-去氧-2'-氟-2'-C-甲基胞苷 |
|---|---|
| 中文同义词 | 2'-脱氧-2'-氟-2'-C-甲基胞苷;2'-去氧-2'-氟-2'-C-甲基胞苷/PSI6130;2'-去氧-2'-氟-2'-C-甲基胞苷;2'-脱氧-2'-氟-2'-C-甲基胞苷 PSI 6130;4-氨基-1-((2R,3R,4R,5R)-3-氟-4-羟基-5-(羟基甲基)-3-甲基四氢呋喃-2-基)嘧啶-2(1H)-酮;抗丙肝病毒药物PSI-6130;索非布韦杂质106;2'-脱氧-2'-氟-2'-C-甲基胞苷(2'-F-2'-ME-DC) |
| 英文名称 | 2'-deoxy-2'-fluoro-2'-C-methylcytidine |
| 英文同义词 | (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine;PSI-6130;R 1656;PSI 6130;4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyr;2'-deoxy-2'-fluoro-2'-C-methylcytidine;R 1656;ethyl 4-broMo-1-Methyl-pyrrole-2-carboxylate;4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimi;4-AMino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidin-2(1H)-one |
| CAS号 | 817204-33-4 |
| 分子式 | C10H14FN3O4 |
| 分子量 | 259.23 |
| EINECS号 | 200-001-2 |
| 相关类别 | 代谢;医药中间体;apis |
| Mol文件 | 817204-33-4.mol |
| 结构式 |  |
2'-去氧-2'-氟-2'-C-甲基胞苷 性质
| 熔点 | 216-218℃ |
|---|---|
| 沸点 | 482.4±55.0 °C(Predicted) |
| 密度 | 1.67 |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 酸度系数(pKa) | 12.86±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至浅棕色 |
| 稳定性 | 吸湿性 |
IC50: 0.6 μM (HCV replication)
PSI-6130 exhibits potent and specific inhibitory activity against HCV RNA replication mediated by the NS5B polymerase. Both PSI-6130 inhibit HCV GT-1b (Con1 strain) and GT-1a (H77 strain) subgenomic RNA replication, with mean EC 50 values of 0.51 and 0.30 μM, respectively. PSI-6130 inhibits 40% human serum with EC 50 of 0.51 μM. PSI-6130 inhibits HCV replication with a mean IC 50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC 50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC 50 of 0.13 μM and K i of 0.023 μM.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130 | 817204-33-4 | 2mg | 1500元 |
| 2024/04/30 | HY-10165 | 2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130 | 817204-33-4 | 5mg | 1950元 |