(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐
| 中文名称 | (3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐 |
|---|---|
| 中文同义词 | (3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐;(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇;异桑叶生物碱;阿戈司他;化合物 T19181;D-ISOFAGOMINE; ISOFAGOMINE;(3R,4R,5R)-5-(羟甲基)哌啶-3,4-二醇 |
| 英文名称 | ISOFAGOMINE, HYDROCHLORIDE |
| 英文同义词 | ISOFAGOMINE, HYDROCHLORIDE;(3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL, HYDROCHLORIDE;(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl;IsofagomineHydrochlroide;(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol;3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-;5-Hydroxymethyl-3,4-piperidinediol;D-Isofagomine |
| CAS号 | 169105-89-9 |
| 分子式 | C6H13NO3 |
| 分子量 | 147.17 |
| EINECS号 | |
| 相关类别 | 植物提取物;标准品 -中药标准品;糖-糖block;pharmacetical;Inhibitors |
| Mol文件 | 169105-89-9.mol |
| 结构式 |  |
(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐 性质
| 沸点 | 317.2±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.279±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.19±0.60(Predicted) |
Afegostat 是一种药理学伴侣，高亲和力且特异性和可逆地结合内质网 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。
GCase
Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.