4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
中文名称 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 |
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中文同义词 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物;4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑鎓氯化物;4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑-3-鎓氯化物;4,5-二甲基-3-(2-氧代-2-苯乙基)-噻唑氯化物;4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物(ALT-711);阿拉氯胺;4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 |
英文名称 | Alagebrium chloride |
英文同义词 | 2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride;Dimethyl-3-(2-oxo-2-phenyl)-chloride;(Alagebrium) (thiazolium salt);4,5-Dimethyl-3-(2-oxo-2-phenyl)-thiazoliumchloride;2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone chloride;2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenyl-ethanone chloride;250g - 1kg;4,5 diMethyl 3-2 (2 oxo-2 phenyl) chloride |
CAS号 | 341028-37-3 |
分子式 | C13H14ClNOS |
分子量 | 267.77 |
EINECS号 | 636-473-0 |
相关类别 | |
Mol文件 | 341028-37-3.mol |
结构式 |
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 性质
熔点 | 212 °C(dec.) |
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储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
颜色 | 白色至类白色 |
Merck | 14,203 |
CAS 数据库 | 341028-37-3(CAS DataBase Reference) |
AGE
Alagebrium chloride is an advanced glycation end product ( AGE ) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats.
Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium.
安全信息
海关编码 | 2934.99.4400 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | XW0234102837303 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 | 341028-37-3 | 1G | 88元 |
2024/04/30 | XW0234102837304 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 | 341028-37-3 | 5G | 339元 |