地西拉嗪
| 中文名称 | 地西拉嗪 |
|---|---|
| 中文同义词 | 地西拉嗪;化合物 T19286 |
| 英文名称 | 2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol |
| 英文同义词 | 2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethoxy]ethanol;Dixyrazine;2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]ethanol;Esucos;UCB-3412;2-[2-[4-(2-methyl-3-phenothiazin-10-yl-propyl)piperazin-1-yl]ethoxy]ethanol;2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]ethanol;Ethanol,2-[2-[4-[2-methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]- |
| CAS号 | 2470-73-7 |
| 分子式 | C24H33N3O2S |
| 分子量 | 427.6 |
| EINECS号 | 219-591-3 |
| 相关类别 | |
| Mol文件 | 2470-73-7.mol |
| 结构式 |  |
地西拉嗪 性质
| 熔点 | 192 °C |
|---|---|
| 沸点 | 590.0±50.0 °C(Predicted) |
| 密度 | 1.0745 (rough estimate) |
| 折射率 | 1.6740 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | pKa1: 7.8; pKa2: 3.65(at 25℃) |
Pretreatment with Dixyrazine 10 mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF). The phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126 I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, 5 mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats.