BMS303141
中文名称 | BMS303141 |
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中文同义词 | 3,5-二氯-2-羟基-N-(4-甲氧基[1,1'-联苯]-3-基)苯磺酰胺;BMS 303141,ATP柠檬酸裂解酶抑制剂;3,5-二氯-2-羟基-N-(4-甲氧基[1,1'-联苯]-3-基)苯磺酰胺 |
英文名称 | BMS 303141 |
英文同义词 | BMS 303141;BMS30314;3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide;3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)benzenesulfonamide;3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide BMS 303141;BMS 303141, >=98%;3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide;CS-887 |
CAS号 | 943962-47-8 |
分子式 | C19H15Cl2NO4S |
分子量 | 424.3 |
EINECS号 | |
相关类别 | 小分子抑制剂,天然产物;小分子抑制剂;Inhibitors |
Mol文件 | 943962-47-8.mol |
结构式 |
BMS303141 性质
沸点 | 591.5±60.0 °C(Predicted) |
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密度 | 1.462±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 在DMSO中的溶解度为20mg/mL,澄清 |
酸度系数(pKa) | 4.94±0.48(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达3个月。 |
Target | Value |
ACL
(Cell-free assay) | 0.13 μM |
In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC 50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity.
Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-16107 | BMS303141 BMS-303141 | 943962-47-8 | 5mg | 650元 |
2024/04/30 | S0277 | BMS303141 BMS303141 | 943962-47-8 | 5mg | 668.92元 |