PRT4165
| 中文名称 | PRT4165 |
|---|---|
| 中文同义词 | 2-(3-吡啶亚甲基)-1,3-茚满二酮;H2A泛素化抑制剂(PRT4165);化合物PRT 4165;PRT4165游离态;2-(吡啶-3-基亚甲基)-1H-茚-1,3(2H)-二酮;2-(3-吡啶基甲基)-1H-茚-1,3(2H)-二氧乙烯;PRT 4165,BMI1 / RING1A抑制剂 |
| 英文名称 | NSC 600157 |
| 英文同义词 | 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(3-Pyridylmethylene)-1,3-indandione;NSC 600157;PRT4165;PRT 4165(NSC 600157);PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157;2-(pyridin-3-ylmethylidene)indene-1,3-dione;1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)- |
| CAS号 | 31083-55-3 |
| 分子式 | C15H9NO2 |
| 分子量 | 235.24 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 31083-55-3.mol |
| 结构式 |  |
PRT4165 性质
| 熔点 | 154-161 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 沸点 | 377.63°C (rough estimate) |
| 密度 | 1.1757 (rough estimate) |
| 折射率 | 1.6231 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.24±0.12(Predicted) |
| 颜色 | 白色至米色 |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月。 |
PRC1
PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. In vitro E3 ubiquitin ligase activity assays reveal that PRT4165 inhibits both RNF2 and RING 1A, but not RNF8 nor RNF168. In the presence of PRT4165, H2A ubiquitylation can be completely inhibited regardless of whether RING1 or RNF2 contributes the E3 ubiquitin ligase activity. Treatment of cells for 60 min with 50 μM PRT4165 results in a dramatic reduction in total ubiquitylated histone H2A. It is also found that longer exposure of the cells with the PRT4165 (30 and 60 min) leads to increased levels of γ-H2AX in unirradiated cells. PRT4165 inhibits double-strand break (DSB) repair at the 8-h time point compare with mock treated cells. Cells treated with increasing concentrations of PRT4165 show increasing numbers of cells in G 2 /M.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | NK6710000 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19817 | PRT4165 PRT4165 | 31083-55-3 | 5mg | 416元 |
| 2024/04/30 | HY-19817 | PRT4165 PRT4165 | 31083-55-3 | 10mM * 1mLin DMSO | 500元 |