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2-Diethylaminoethylchloride hydrochloride

2-Diethylaminoethylchloride hydrochloride Basic information
Product Name:2-Diethylaminoethylchloride hydrochloride
Synonyms:3,5-DIMETHOXYANISOLE;(2-chloroethyl)diethylaminemonohydrochloride;1-chloro-2-(diethylamine)ethanehydrochloride;2-chloroethyl-n,n-diethylaminehydrochloride;TRISMETHOXYBENZENE;2-chloro-n,n-diethyl-ethanaminhydrochloride;2-Chlorotriethylaminehydrochl;2-chloro-triethylaminhydrochloride
CAS:869-24-9
MF:C6H15Cl2N
MW:172.1
EINECS:212-786-4
Product Categories:Aliphatics;Miscellaneous Reagents
Mol File:869-24-9.mol
2-Diethylaminoethylchloride hydrochloride Structure
2-Diethylaminoethylchloride hydrochloride Chemical Properties
Melting point 50-53 °C(lit.)
Boiling point 255 °C(lit.)
density 1.1919 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.6000 (estimate)
Fp 186 °F
storage temp. Poison room
solubility methanol: 0.1 g/mL, clear, colorless
form Crystalline Powder
color White to slightly beige
PH5 (100g/l, H2O, 20℃)
Water Solubility 2000 g/L (20 ºC)
Sensitive Moisture Sensitive
BRN 3591991
Stability:Hygroscopic, Moisture Sensitive
InChIKeyRAGSWDIQBBZLLL-UHFFFAOYSA-N
CAS DataBase Reference869-24-9(CAS DataBase Reference)
EPA Substance Registry SystemDiethyl-(2-chloroethyl)amine hydrochloride (869-24-9)
Safety Information
Hazard Codes Xn,T,Xi,T+
Risk Statements 22-36/37/38-26-24/25-23/24/25
Safety Statements 26-36-45-36/37/39-28A
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS DC2810000
Hazard Note Irritant/Very Toxic
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29211980
Hazardous Substances Data869-24-9(Hazardous Substances Data)
MSDS Information
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2-Diethylaminoethylchloride hydrochloride Usage And Synthesis
Chemical Properties2-Diethylaminoethylchloride hydrochloride is colourless to beige crystals
Uses2-Chloro-N,N-diethylethylamine hydrochloride (65% in water) (DEC 65) is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet
Uses2-Chloro-N,N-diethylethylamine hydrochloride can be used as an alkylating reagent for the synthesis of:
  • Substituted oxindole derivatives to be used as growth hormone secretagogs.
  • 1-Substituted-5,6-dinitrobenzimidazoles with antimicrobial and antiprotozoal activities.
  • Thiophene containing triarylmethane (TRAM) derivatives to be used as antitubercular agents.
  • Tris(2-(diethylamino)ethyl)amine to be used as a catalyst in combination with CuBr (Et6TREN/CuBr) for atom transfer radical polymerization of n-butyl acrylate.

It can also be used for the derivatization of chitosan to incorporate aminofunctionality onto it at C-6 position.
Uses2-Diethylaminoethylchloride hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet
Purification MethodsCrystallise the salt from absolute MeOH (to remove highly coloured impurities). [Beilstein 4 III 240.]
2-Diethylaminoethylchloride hydrochloride Preparation Products And Raw materials
Raw materialsDiethylaminoethanol
Preparation ProductsN-(3-Trifluoromethylphenyl)piperazine-->1-(2-Methoxyphenyl)piperazine-->CAMYLOFINE DIHYDROCHLORIDE-->Tilorone dihydrochloride
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