| Company Name: |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
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| Tel: |
17691182729 18161915376 |
| Email: |
1046@dideu.com |
| Products Intro: |
Product Name:2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate
CAS:5061-22-3
Purity:98% Package:25KG
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Nafiverine;Nafiverine
CAS:5061-22-3
Purity:98% Package:5 mg
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| | nafiverine Basic information |
| Product Name: | nafiverine | | Synonyms: | Bis(α-methyl-1-naphthaleneacetic acid)2,2'-(1,4-piperazinediyl)bisethyl ester;DA-914;Naftimepezine;nafiverine;1-Naphthaleneacetic acid, α-methyl-, 1,1'-(1,4-piperazinediyldi-2,1-ethanediyl) ester;EINECS 225-766-5;Nafiverina;Nafiverinum | | CAS: | 5061-22-3 | | MF: | C34H38N2O4 | | MW: | 538.684 | | EINECS: | 2257665 | | Product Categories: | | | Mol File: | 5061-22-3.mol |  |
| | nafiverine Chemical Properties |
| | nafiverine Usage And Synthesis |
| Originator | Naftidan,De Angeli,Italy,1969 | | Definition | ChEBI: Nafiverine is a member of naphthalenes. | | Manufacturing Process | 15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of
thionyl chloride during 3 hours. The excess thionyl chloride was removed
under reduced pressure and the product was also isolated by distillation under
reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl
chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)-
piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1-
naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with
stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester
were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared
by dissolving the ester in absolute ethanol and treating the solution with
anhydrous gaseous hydrogen chloride. | | Therapeutic Function | Spasmolytic |
| | nafiverine Preparation Products And Raw materials |
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