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| | 4-O-(Carboxymethyl)rifamycin Basic information |
| | 4-O-(Carboxymethyl)rifamycin Chemical Properties |
| Melting point | 300° (dec 160-164°) | | alpha | D20 -11° (methanol) | | Boiling point | 730.16°C (rough estimate) | | density | 1.2421 (rough estimate) | | refractive index | 1.5350 (estimate) | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Sonicated) | | pka | 2.69±0.10(Predicted) | | BRN | 604953 | | Stability: | Unstable in solution |
| Toxicity | LD50 in mice (mg/kg): 2040 i.v., >3000 i.p., s.c., and orally (Sensi, 1964) |
| | 4-O-(Carboxymethyl)rifamycin Usage And Synthesis |
| Uses | Rifamycin B (Rifaximin EP Impurity B) is a Rifamycin (R508200) derivative as antibacterial agent. | | Uses | A Rifamycin (R508200) derivative as antibacterial agent. | | Definition | ChEBI: Rifamycin B is a carboxylic acid, an acetate ester, an organic heterotetracyclic compound and a member of rifamycins. It is a conjugate acid of a rifamycin B(2-). | | Purification Methods | Rifamycin B forms yellow needles from *C6H6. Its solubilities are: H2O (0,027%), MeOH (2.62%) and EtOH (0.44%). It has UV max at 223, 304 and 245nm (A 1cm 555, 275 and 220). [Oppolzer & Prelog Helv Chim Acta 56 2287 1973, Oppolzer et al. Experientia 20 336 1964, X-ray: Brufani et al. Experientia 20 339 1964.] |
| | 4-O-(Carboxymethyl)rifamycin Preparation Products And Raw materials |
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