- Ametantrone
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- $0.50 / 1g
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2020-01-10
- CAS:64862-96-0
- Min. Order: 1g
- Purity: 98%min
- Supply Ability: 10g,100g,1kg
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| | Ametantrone Basic information |
| Product Name: | Ametantrone | | Synonyms: | Ametantrone;1,4-Bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthraquinone;HAQ;NSC-287513;NSC 196473;NSC 290813;AMetantrone(NSC 196473);1,4-BIS(2-(2-HYDROXYETHYLAMINO)ETHYLAMINO)ANTHRACENE-9,10-DIOL | | CAS: | 64862-96-0 | | MF: | C22H28N4O4 | | MW: | 412.48 | | EINECS: | | | Product Categories: | | | Mol File: | 64862-96-0.mol |  |
| | Ametantrone Chemical Properties |
| Melting point | 156-158 °C | | Boiling point | 531.92°C (rough estimate) | | density | 1.2344 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 14.47±0.10(Predicted) |
| | Ametantrone Usage And Synthesis |
| Description | Ametantrone is an inhibitor of topoisomerase II. It induces double-strand breaks in SV40 DNA in the presence, but not absence, of topoisomerase II and induces single-strand breaks in DNA in NCI H187 cells. It also induces interstrand DNA cross-links in HeLa S3 cells at a minimum concentration of 4.1 μM. Ametantrone is cytotoxic to NCI H187 and HL-60 cells (IC50s = 112 and 0.44 μM, respectively). It inhibits tumor growth in a Ridgway osteogenic sarcoma mouse model when administered at a dose of 5 mg/kg, however, it increases tumor growth in mouse models of mammary adenocarcinoma and colon adenocarcinoma 11a. |
| | Ametantrone Preparation Products And Raw materials |
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