- fg-4592 int 2
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- $5.50 / 1KG
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2019-09-06
- CAS:1421312-34-6
- Min. Order: 2KG
- Purity: 96%-99%
- Supply Ability: 100kg
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| | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Basic information |
| Product Name: | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester | | Synonyms: | fg-4592 int 2;1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate;4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester;Fg-4592/FG4592 int 2;ROXA-019;methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate;3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester;4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid | | CAS: | 1421312-34-6 | | MF: | C18H15NO4 | | MW: | 309.32 | | EINECS: | | | Product Categories: | API | | Mol File: | 1421312-34-6.mol |  |
| | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties |
| Boiling point | 537.3±45.0 °C(Predicted) | | density | 1.289±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere, 2-8°C | | pka | 6.24±0.50(Predicted) |
| | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Usage And Synthesis |
| Uses | 4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency. | | Preparation | Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%). |
| | 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials |
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