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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE

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2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SCH28080
CAS:76081-98-6
Package:5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:SCH-28080
CAS:76081-98-6
Purity:95% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:SCH 28080
CAS:76081-98-6
Purity:98% Package:$112.9/5mg;$172.9/10mg;$389.9/25mg;$701.9/50mg;$1261.9/100mg;Bulk package Remarks:98%
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:SCH 28080;2-Methyl-8-(phenylMethoxy)iMidazo[1,2-a]pyridine-3-acetonitrile
CAS:76081-98-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:SCH-28080
CAS:76081-98-6
Purity:>=98% (HPLC), solid Package:10MG Remarks:S4443-10MG
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Basic information
Product Name:2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE
Synonyms:3-(CYANOMETHYL)-2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-ALPHA]PYRIDINE;2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE;2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile;Imidazo(1,2-A)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-;S28080;Schering compound 28080;SCH 28080;imidazo-(1-2-a)pyrine-3-acetonitrile
CAS:76081-98-6
MF:C17H15N3O
MW:277.32
EINECS:
Product Categories:ATPase
Mol File:76081-98-6.mol
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Structure
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Chemical Properties
density 1.16±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >10 mg/mL, soluble
form solid
pka5.85±0.10(Predicted)
color white to light tan
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Usage And Synthesis
DescriptionSCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 μM). It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.
UsesSCH 28080 is a potent inhibitor of H+,K+-ATPase.
DefinitionChEBI: 2-(2-methyl-8-phenylmethoxy-3-imidazo[1,2-a]pyridinyl)acetonitrile is an imidazopyridine.
Biological ActivityPotent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .
Biochem/physiol ActionsSCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.
storageRoom temperature
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE Preparation Products And Raw materials
Tag:2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE(76081-98-6) Related Product Information
4(5)-CYANOMETHYLIMIDAZOLE 2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE (1,4-DIMETHYL-1H-IMIDAZOL-2-YL)METHANOL 2-Methylimidazo[1,2-a]pyridin-8-ol 8-BENZYLOXY-IMIDAZO[1,2-A]PYRIDINE 3-Cyanomethyl-2-methylimidazo(1,2-a)pyridine (1-Methyl-1H-imidazol-2-yl)methanol Imidazo[1,2-a]pyridin-8-ol (9CI) IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE