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| | 3-Guanidinopropionic acid Basic information |
| Product Name: | 3-Guanidinopropionic acid | | Synonyms: | b-Alanine, N-(aMinoiMinoMethyl)-;guanidinepropanoicacid;guanidinopropionicacid;n-(aminoiminomethyl)-beta-alanin;n-(aminoiminomethyl)beta-alanine;3-(diaminomethylideneamino)propanoic acid;3-[bis(azanyl)methylideneamino]propanoic acid;GUANIDINOPROPIONIC ACID(P) | | CAS: | 353-09-3 | | MF: | C4H9N3O2 | | MW: | 131.13 | | EINECS: | 206-530-0 | | Product Categories: | | | Mol File: | 353-09-3.mol |  |
| | 3-Guanidinopropionic acid Chemical Properties |
| Melting point | 222 °C (dec.)(lit.) | | Boiling point | 299.1±42.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Aqueous Acid (Slightly), Water (Slightly, Heated) | | form | Solid | | pka | 4.22±0.10(Predicted) | | color | White to Off-White | | BRN | 1705262 | | LogP | -1.680 (est) | | CAS DataBase Reference | 353-09-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | AY3157500 | | HS Code | 29252900 |
| | 3-Guanidinopropionic acid Usage And Synthesis |
| Description | Guanidinopropionic acid is a white crystal that dissolves in water and is a creatine analog. Guanidinopropionic acid is a kind of amino acid derivatives. It is an important chemical raw material and intermediate. It exists in the serum, brain, liver, kidney and urine of mammals. It can improve insulin sensitivity and selectively reduce Adipose tissue weight can treat and prevent metabolic disorders, hyperglycemia, hyperinsulinemia, insensitivity to blood insulin, hyperlipidemia, hyperamylase, obesity and other symptoms. | | Chemical Properties | White solid | | Uses | 3-Guanidinopropionic Acid is an acidic guanidine derivative that has been shown to ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes. | | Definition | ChEBI: 3-guanidinopropanoic acid is a guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels It has a role as a hypoglycemic agent. It derives from a propionic acid. It is a tautomer of a 3-guanidinopropanoic acid zwitterion. | | Synthesis | Using thiourea |?-alanine as a raw material, guanidinopropionic acid is prepared by a two-step alkylation reaction of nucleophilic substituted amine, the content is greater than 99.0%, and the total yield is 76.2%. The process is low cost, mild conditions, and easy operation, simple and suitable for industrial production.
 | | references | [1] winder w w, hardie d g. amp-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes[j]. american journal of physiology-endocrinology and metabolism, 1999, 277(1): e1-e10.
[2] chaturvedi, r. k.,adhihetty, p.,shukla, s., et al. impaired pgc-1α function in muscle in huntington’s disease. human molecular genetics 18(16), 3048-3065 (2009).
[3] larsen s d, connell m a, cudahy m m, et al. synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent[j]. journal of medicinal chemistry, 2001, 44(8): 1217-1230.
[4] meglasson m d, wilson j m, yu j h, et al. antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys[j]. journal of pharmacology and experimental therapeutics, 1993, 266(3): 1454-1462. |
| | 3-Guanidinopropionic acid Preparation Products And Raw materials |
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