1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID manufacturers
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| | 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Basic information |
| Product Name: | 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID | | Synonyms: | BUTTPARK 36\04-50;IBC 293;IPBT-5CA;1-ISOPROPYL-1H-BENZO[D][1,2,3]TRIAZOLE-5-CARBOXYLIC ACID;1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-ISOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-ISOPROPYLBENZOTRIAZOLE-5-CARBOXYLIC ACID;1-(1-METHYLETHYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID | | CAS: | 306935-41-1 | | MF: | C10H11N3O2 | | MW: | 205.21 | | EINECS: | | | Product Categories: | | | Mol File: | 306935-41-1.mol |  |
| | 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Chemical Properties |
| Melting point | 229-230°C | | Boiling point | 413.9±18.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | Light brown solid | | pka | 3.50±0.30(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | CAS DataBase Reference | 306935-41-1(CAS DataBase Reference) |
| | 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Usage And Synthesis |
| Description | IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a. | | Definition | ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles. | | Biological Activity | Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes. | | References | 1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227 |
| | 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials |
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