1015073-42-3
中文名称 | 1015073-42-3 |
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中文同义词 | 化合物 T12572;瑞德西韦杂质51 |
英文名称 | PSI7409 |
英文同义词 | PSI 7409;PSI7409;PSI-7409;(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-;sofosbuvir 5‘ - triphosphate;Remdesivir Impurity 51 |
CAS号 | 1015073-42-3 |
分子式 | C10H16FN2O14P3 |
分子量 | 500.16 |
EINECS号 | |
相关类别 | |
Mol文件 | 1015073-42-3.mol |
结构式 |
1015073-42-3 性质
储存条件 | Store at -20°C |
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溶解度 | 甲醇(微溶)、水(微溶) |
形态 | 固体 |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
PSI-7409 inhibits the enzymatic activities of these NS5BΔ21 polymerases in a dose-dependent manner. The IC 50 s for PSI-7409 against GT 1b, 2a, 3a, and 4a NS5B polymerases are 1.6 μM, 2.8 μM, 0.7 μM, and 2.6 μM, respectively. PSI-7409 is a weak inhibitor of DNA Pol α (IC 50 =550 μM). DNA Pol β and γ are not inhibited by 1 mM PSI-7409. A significant amount of RNA product is made in the presence of 500 μM PSI-7409, about 85%. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μm over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ∼100 μM at 4 h and remains at that concentration for 48 h.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2023/03/20 | HY-15745 | 1015073-42-3 PSI-7409 | 1015073-42-3 | 1mg | 2600元 |
2023/03/20 | HY-15745 | 1015073-42-3 PSI-7409 | 1015073-42-3 | 5mg | 7800元 |