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| | PSI7409 Basic information |
| Product Name: | PSI7409 | | Synonyms: | PSI 7409;PSI7409;PSI-7409;(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-;sofosbuvir 5‘ - triphosphate;Remdesivir Impurity 51 | | CAS: | 1015073-42-3 | | MF: | C10H16FN2O14P3 | | MW: | 500.16 | | EINECS: | | | Product Categories: | | | Mol File: | 1015073-42-3.mol |  |
| | PSI7409 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | PSI7409 Usage And Synthesis |
| Uses | (2'R)??-2'-??Deoxy-??2'-??fluoro-??2'-??methyl-uridine 5'-??Triphosphate Tetrasodium Salt is an impurity of Sofosbuvir (P839640) which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate. |
| | PSI7409 Preparation Products And Raw materials |
| Raw materials | 2,4(1H,3H)-Pyrimidinedione, 1-[2-C-methyl-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-arabinofuranosyl]--->1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione-->1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione-->PSI 7411-->2'-deoxy-2'-fluoro-2'-C-methyluridine-->3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine-->Uridine |
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