1,2-脱水肌醇
中文名称 | 1,2-脱水肌醇 |
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中文同义词 | 脱水肌醇;环己烯四醇Β环氧化物(脱水肌醇);1,2-脱水肌醇;环己烯四醇Β环氧化物;REL-(1R,2R,3S,4S,5R,6S)-7-氧杂二环[4.1.0]庚烷-2,3,4,5-四醇 |
英文名称 | CONDURITOL B EPOXIDE |
英文同义词 | conduritolepoxide;(+/-) CONDURITOL B EPOXIDE;CONDURITOL B EPOXIDE;DL-1,2-ANHYDRO-MYO-INOSITOL;1,2-Anhydro-myo-inositol;(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol;myo-Inositol, 1,2-anhydro- (9CI);4h-3,1-benzoxazin-4-one, 5-methyl-2-(3-nitrophenyl)- |
CAS号 | 6090-95-5 |
分子式 | C6H10O5 |
分子量 | 162.14 |
EINECS号 | |
相关类别 | 抑制剂;小分子;EPOXYDE;All Inhibitors;Glycosidase Inhibitors;Inhibitors;api |
Mol文件 | 6090-95-5.mol |
结构式 |
1,2-脱水肌醇 性质
熔点 | 157-159 |
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沸点 | 360.5±42.0 °C(Predicted) |
密度 | 1.925±0.06 g/cm3 (20 ºC 760 Torr) |
储存条件 | 2-8°C |
溶解度 | 可溶于水(高达25mg/ml)或DMSO |
酸度系数(pKa) | 13.08±0.70(Predicted) |
形态 | 白色固体 |
颜色 | 白色 |
稳定性 | 湿气敏感 |
Treating N2a and Conduritol B epoxide-N2a cells with G6 gave GC reductions to 7% and 26% of untreated levels, respectively. G6 treated Conduritol B epoxide-N2a also has significantly decreased GS. Co-treatment of G6 and dantrolene of Conduritol B epoxide-N2a cells lead to a similar degree of GC and GS reduction as G6 alone, indicating a specific effect of G6 on inhibition of substrate accumulation, Conduritol B epoxide-N2a cells have higher calcium levels than in N2a cells without caffeine at baseline. Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells. Conduritol B epoxide-N2a cells show a significant reduction in OCR as evidenced by approximately 50% in all the parameters, including rate of ATP production, basal respiration, and maximal respiration, compared to N2a cells, indicating reduced mitochondrial function in this nGD cell model. In dantrolene-treated Conduritol B epoxide-N2a cells, levels of Ryr3 are increased to 76% of WT level.
Conduritol B epoxide treatment of 4L, 9H, 9V and WT mice (100 mg/kg/day, i.p.) from postnatal day 5 to 11 does not induce α-synuclein aggregates. Long-term daily Conduritol B epoxide treatment of 4L mice (100 mg/kg/day of Conduritol B epoxide from postnatal day 15 for 24 or 36 doses) leads to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb, brainstem, and PVP near D3V (dorsal 3rd ventricle).
安全信息
WGK Germany | 3 |
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Hazard Note | Harmful |
海关编码 | 2932990090 |
提供商 | 语言 |
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英文
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