| Company Name: |
Sri Krishna Pharmaceuticals Ltd
|
| Tel: |
+91-4027177825 +91-8886992503 |
| Email: |
reena@srikrishnapharma.com |
| Products Intro: |
Product Name:Fenoverine
CAS:37561-27-6
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Products Intro: |
Product Name:Fenoverine
CAS:37561-27-6
Purity:Typically NLT 98%
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Fenoverine
CAS:37561-27-6
Purity:98% Package:100 mg；5 mg；50 mg
|
|
| | FENOVERINE Basic information |
| Product Name: | FENOVERINE | | Synonyms: | FENOVERINE;10-[(4-Piperonyl-1-piperazinyl)acetyl]-10H-phenothiazine;Spasmopriv;3-chloro-3-oxopropanoic acid ethyl ester;Fenoverine D8;Ethanone, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(10H-phenothiazin-10-yl)- | | CAS: | 37561-27-6 | | MF: | C26H25N3O3S | | MW: | 459.56 | | EINECS: | 253-552-1 | | Product Categories: | | | Mol File: | 37561-27-6.mol |  |
| | FENOVERINE Chemical Properties |
| Melting point | 141-142° | | Boiling point | 671.8±55.0 °C(Predicted) | | density | 1.343±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 6.47±0.10(Predicted) | | form | Solid | | color | Pale Beige to Beige | | Stability: | Hygroscopic |
| Toxicity | LD50 in mice (g/kg): ~1.50 orally, ~2.50 i.p. (Buzas, Pierre) |
| | FENOVERINE Usage And Synthesis |
| Originator | Spasmopriv,Paillusseau | | Uses | Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs. | | Definition | ChEBI: Fenoverine is a member of phenothiazines. | | Manufacturing Process | To a hot solution 199.3 g (0.1 mol) of phenothiazine in 2 L of dry benzene
was added a little quantity of bromine and then were added dropwise 136 g
(0.1 mol) of chloroacetyle chloride. Then a mixture was refluxed for 5 hours.
After cooling the mixture was concentrated in vacuo. Product was dissolved at
reflux in ethanol absolute and filtered. At room temperature was crystallized
chloracetyl-10-phenothiazine with 123°C; yield 242 g.
A mixture of 13.8 g (0.05 mol) of chloracetyl-10-phenothiazine, 11.8 g (0.05
mol) of piperonyl-1-piperazine and 3.9 g (0.05 mol) of pyridine in 200 ml of
dry toluene was refluxed for 3 hours. Then the solution was cooled and
filtered. The filtrate was concentrated. The crystals of 10-((4-piperonyl-1-
piperazinyl)acetyl)phenothiazine was recrystallized from isopropylic ether; M.P.
141-142°C; yield 67%. | | Therapeutic Function | Spasmolytic |
| | FENOVERINE Preparation Products And Raw materials |
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