离子霉素
| 中文名称 | 离子霉素 |
|---|---|
| 中文同义词 | 罗红霉素(游离酸)(链霉菌属载体);离子霉素;离子霉素, 来源于链霉菌;离子霉素(乙醇溶液);来自共生链霉菌的IONOMYCIN;IONOMYCIN游离态;碘霉素;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-三羟基-22-((2S,2'R,5S,5'S)-5'-((R)-1-羟乙基)-2,5'-二甲基八氢-[2,2'-联呋喃]-5-基)-4,6,8,12,14,18,20-七甲基-9-氧代二十二烷-10,16-二烯酸 |
| 英文名称 | IONOMYCIN |
| 英文同义词 | (4R,6S,8R,12R,14S,18S,19R,20R,21R)-19,21-Dihydroxy-22-[(2R,5R)-5-[(2R,5S)-5-(1-hydroxyethyl)-5-methyl-oxolan-2-yl]-5-methyl-oxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-docosa-10,16-dienoate calcium salt;SQ-23377;Ionomycin,Free Acid,from Streptomyces conglbatus;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid;SQ 23377, EM 94;Ionomycin, free acid, from Streptomyces conglobatus;(4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2'S,5S,5'R)-5'-[(1S)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid;ionomycin calcium salt from streptomyces conglobatus |
| CAS号 | 56092-81-0 |
| 分子式 | C41H72O9 |
| 分子量 | 709.01 |
| EINECS号 | |
| 相关类别 | 抗生素;微生物代谢物;医药原料;试剂盒-细胞分析试剂盒;抗体;MiscellaneousMore...Close...;A - KResearch Essentials;Antibacterial;Antibiotics A to;Antibiotics by Application;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Calcium channel;Ion Channels;antibiotic;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Spectrum of Activity |
| Mol文件 | 56092-81-0.mol |
| 结构式 |  |
离子霉素 性质
| 沸点 | 817.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.072±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 在乙醇中水中的溶解度为至10mM，在DMSO中水中的溶解度为至10mM。 |
| 形态 | 蜡状固体 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 颜色 | 粘黄色 |
| BRN | 3642126 |
| 稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达3个月。 |
Calcium ionophore
Ionomycin is a Calcium ionophore and an antibiotic produced by
Streptomyces conglobatus
.
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca
2+
concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 22-36/37/38 |
| 安全说明 | 36-36/37/39-27-26-24/25 |
| WGK Germany | 3 |
| RTECS号 | NO0650000 |
| F | 8-10 |
| 危险等级 | 3 |
| 海关编码 | 29419090 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-13434 | 离子霉素 Ionomycin | 56092-81-0 | 1mg(14.1mM * 100μL in Ethanol) | 1450元 |
| 2024/04/30 | HY-13434 | 离子霉素 Ionomycin | 56092-81-0 | 5mg(14.1mM * 500μL in Ethanol) | 3900元 |