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| Product Name: | Methylaminoformyl chloride | | Synonyms: | METHYLCARBAMOYLCHLORIDE;METHYLAMINOFORMYL CHLORIDE;N-Methylchloroformamide;Methylcarbamic acid chloride;N-(Chloroformyl)methylamine;N-Methylcarbamoyl chloride;CarbaMic chloride,Methyl- (9CI);Carbamic chloride, N-methyl- | | CAS: | 6452-47-7 | | MF: | C2H4ClNO | | MW: | 93.51 | | EINECS: | 229-253-7 | | Product Categories: | Agrochemicals | | Mol File: | 6452-47-7.mol |  |
| | Methylaminoformyl chloride Chemical Properties |
| Melting point | 45°C | | Boiling point | 93°C (dec.) | | density | 1.185±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Acetonitrile, Chloroform (Slightly), DMSO | | form | Solid | | pka | 10.67±0.46(Predicted) | | color | White to Off-White | | Stability: | Air Sensitive, Hygroscopic, Moisture Sensitive, Volatile | | CAS DataBase Reference | 6452-47-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | Methylaminoformyl chloride Usage And Synthesis |
| Description | Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
| | Uses | Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
| | Preparation | Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].
| | Uses | Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. | | Synthesis Reference(s) | Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009 |
| | Methylaminoformyl chloride Preparation Products And Raw materials |
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