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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:NO-Losartan A
CAS:791122-48-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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Product Name:NO-LOSARTAN A
CAS:791122-48-0
Purity:98% Package:5mg; 50mg; 10mg; 1mg Remarks:Medbio
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| Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
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Product Name:NO-Losartan A;NOLosartan A,NO Losartan A
CAS:791122-48-0
Purity:98% Package:100 mg
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:NO-Losartan A
CAS:791122-48-0
Purity:97% Package:1mg;5mg;10mg
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| Company Name: |
Cayman Chemical Company
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(800) 364-9897 |
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cayman@caymanchem.com |
| Products Intro: |
Product Name:NO-Losartan A
CAS:791122-48-0
Package:>=97% Remarks:10006456
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|
| | NO-LOSARTAN A Basic information |
| Product Name: | NO-LOSARTAN A | | Synonyms: | [2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOL-5-YL] METHYL ESTER 3-[(NITROOXY)METHYL]-BENZOIC ACID;NO-LOSARTAN A;MWJCPZGVGOVWQZ-UHFFFAOYSA-N;NOLosartan A,NO Losartan A;Benzoic acid, 3-[(nitrooxy)methyl]-, [2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl]methyl ester | | CAS: | 791122-48-0 | | MF: | C30H28ClN7O5 | | MW: | 602.04 | | EINECS: | | | Product Categories: | | | Mol File: | 791122-48-0.mol |  |
| | NO-LOSARTAN A Chemical Properties |
| Boiling point | 818.4±75.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:5): .5 mg/ml | | form | A crystalline solid | | pka | 4.16±0.10(Predicted) |
| | NO-LOSARTAN A Usage And Synthesis |
| Description | Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.3 In humans, losartan effectively controls hypertension while protecting renal function.4 Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.5,6 NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.7 | | References | 1. Ortiz, M.C., Sanabria, E., Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II Hypertension 37(2),505-511(2001).
2. Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression Am. J. Hypertens. 15(10 Pt 2),115S-122S(2002).
3. Ji, H., Leung, M., Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan J. Biol. Chem. 269(24),16533-16536(1994).
4. Caruso, D., D'Avino, M., Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions J. Cardiovasc. Pharmacol. 44(5),520-524(2004).
5. Moncada, S., and Higgs, A. The L-arginine-nitric oxide pathway N. Engl. J. Med. 329,2002-2012(1993).
6. Loscalzo, J., and Welch, G. Nitric oxide and its role in the cardiovascular system Prog. Cardiovasc. Dis. 38,87-103(1995).
7. Breschi, M.C., Calderone, V., Digiacomo, M., et al. NO-sartans: A new class of pharmacodynamic hybrids as cardiovascular drugs J. Med. Chem. 47,5597-5600(2004). |
| | NO-LOSARTAN A Preparation Products And Raw materials |
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