四氢生物喋呤
| 中文名称 | 四氢生物喋呤 |
|---|---|
| 中文同义词 | 四氢生物喋呤;(6R,S)-5,6,7,8-四氢-L-生物蝶呤二盐酸盐;化合物 T17056 |
| 英文名称 | Tetrahydrobiopterin |
| 英文同义词 | 5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinon;5,6,7,8-tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1h)-pteridinone;bh4;TETRAHYDRO-L-BIOPTERIN, DIHYDROCHLORIDE;THB, 2HCL;6R-BH4;(6R)-BH4 2HCL;[6R-[6R*(1R*,2S*)]]-2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-5,6,7,8-TETRAHYDRO-4(1H)-PTERIDINONE DIHYDROCHLORIDE |
| CAS号 | 17528-72-2 |
| 分子式 | C9H15N5O3 |
| 分子量 | 241.25 |
| EINECS号 | |
| 相关类别 | 医药中间体;对照品-标准品 |
| Mol文件 | 17528-72-2.mol |
| 结构式 |  |
四氢生物喋呤 性质
| 熔点 | >202°C (dec.) |
|---|---|
| 沸点 | 506.6±60.0 °C(Predicted) |
| 密度 | 1.89±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 可溶于酸性水溶液（少许）、DMSO（少许）、水（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.22±0.20(Predicted) |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
|
Human Endogenous Metabolite
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MicMicroglial cell cultures under hyperoxia are supplemented or not with an effective dose of Tetrahydrobiopterin (BH4) (100 μM). Exposure of microglial cells to hyperoxia-induced oxidative stress for 24 h reveals a robust increase in TSP-1 mRNA expression and protein compare to normoxia (21% O 2 ). Tetrahydrobiopterin supplementation significantly prevents hyperoxia-induced microglial activation by diminishing Iba-1 and TSP-1 expression and prevents microvascular injury in choroidal explants.
To assess the levels of Tetrahydrobiopterin in the retina, three to five pools of retinas are collected from WT and hph-1mice at postnatal age 7, 14, and 22 and evaluated by LC-MS/MS. LC-MS/MS analysis confirm a significant decrease by approximately 90% in the concentration levels of Tetrahydrobiopterin in retinal tissue from hph-1 mice (0.0009±0.0006; p<0.0001, 0.01±0.001; p<0.0001 and 2.45±0.40; p<0.005) compare to the WT group (0.014±0.001, 0.092±0.01, and 23.13±6.44) at P7, P14, and P22, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-107383 | 四氢生物喋呤 Tetrahydrobiopterin | 17528-72-2 | 5mg | 1125元 |
| 2024/04/30 | HY-107383 | 四氢生物喋呤 Tetrahydrobiopterin | 17528-72-2 | 10mM * 1mLin DMSO | 1238元 |