| Company Name: |
9ding chemical ( Shanghai) Limited
|
| Tel: |
4009209199 |
| Email: |
sales@9dingchem.com |
| Products Intro: |
Product Name:3-Cyano-4-methylphenylboronic acid, pinacol ester
CAS:1220219-11-3
Purity:98%
|
| Company Name: |
ShangHai AmK Pharmaceutical Technology Co., Ltd.
|
| Tel: |
18019252918 |
| Email: |
sale@amkchem.com |
| Products Intro: |
Product Name:2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
CAS:1220219-11-3
Purity:0.97 Package:1g,10g,100g
|
|
| | 3-Cyano-4-methylphenylboronic acid, pinacol ester Basic information |
| Product Name: | 3-Cyano-4-methylphenylboronic acid, pinacol ester | | Synonyms: | 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;3-Cyano-4-methylphenylboronic acid, pinacol ester;Benzonitrile, 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- | | CAS: | 1220219-11-3 | | MF: | C14H18BNO2 | | MW: | 243.11 | | EINECS: | | | Product Categories: | | | Mol File: | 1220219-11-3.mol |  |
| | 3-Cyano-4-methylphenylboronic acid, pinacol ester Chemical Properties |
| Boiling point | 354.8±35.0 °C(Predicted) | | density | 1.05±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C |
| | 3-Cyano-4-methylphenylboronic acid, pinacol ester Usage And Synthesis |
| Chemical Properties | 3-Cyano-4-methylphenylboronic acid, pinacol ester, also named as 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, is a white solid. | | Preparation | 5-Bromo-2-methylbenzonitrile (40 g, 204 mmol), bis(pinacolato)diboron (69.2 g, 306 mmol), potassium acetate (60 g, 612 mmol), PdCl2(dppf) (7.6 g, 20.8 mmol) and 1,4-dioxane (500 mL) were added in a 1 L single-neck flask, and the reaction mixture was heated to react at 100 ℃ for 2 hours.
After completion of the reaction, the mixture was cooled to room temperature, then water (250 mL) was added.
The mixture was extracted with ethyl acetate (3?250 mL), and the organic layers were concentrated in vacuo to remove the solvent.
The residue was separated by a silica gel column (petroleum ether: ethyl acetate = 30:1) to give 3-Cyano-4-methylphenylboronic acid, pinacol ester.
 |
| | 3-Cyano-4-methylphenylboronic acid, pinacol ester Preparation Products And Raw materials |
|