BRD7552
| 中文名称 | BRD7552 |
|---|---|
| 中文同义词 | 4-(((((2R,3R,4S,5R,6S)-4,5-双((苯并[D][1,3]二氧戊环-5-基氨基甲酰基)氧基)-2-(羟甲基)-6-甲氧基四氢-2H-吡喃-3-基)氧基)羰基)氨基)苯甲酸乙酯;BRD7552,PDX1转录因子诱导剂 |
| 英文名称 | ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate |
| 英文同义词 | ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate;BRD7552;CS-1560;BRD 7552;BRD-7552;BRD7552;Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside;α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate];BRD7552 >=98% (HPLC);Ethyl 4-(((((2R,3R,4S,5R,6S)-4,5-bis((benzo[d][1,3]dioxol-5-ylcarbamoyl)oxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)carbonyl)amino)benzoate |
| CAS号 | 1137359-47-7 |
| 分子式 | C33H33N3O15 |
| 分子量 | 711.63 |
| EINECS号 | |
| 相关类别 | 活性分子 |
| Mol文件 | 1137359-47-7.mol |
| 结构式 |  |
BRD7552 性质
| 沸点 | 757.6±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.53±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：25mg/mL； DMF:PBS (pH 7.2) (1:5)：0.2 mg/mL； DMSO：20mg/mL；乙醇：10mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 11.81±0.20(Predicted) |
BRD7552 是一种 PDX1 转录因子诱导剂，它上调了人类原代胰岛和导管细胞中 PDX1 的表达，并诱导 PDX1 启动子的表观遗传变化与转录激活一致。BRD7552 增加胰岛素表达。PDX1 是参与胰腺发育和β细胞功能的关键转录因子。
BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells.
BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner.
Western Blot Analysis
| Cell Line: | PANC-1 cells |
| Concentration: | 1.25, 2.5, 5 μM |
| Incubation Time: | 5 days |
| Result: | Induced a dose-dependent increase in PDX1 protein levels. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19694 | BRD7552 BRD7552 | 1137359-47-7 | 5mg | 880元 |
| 2024/04/30 | HY-19694 | BRD7552 BRD7552 | 1137359-47-7 | 10mg | 1250元 |