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| | L-745,870 TRIHYDROCHLORIDE Basic information |
| Product Name: | L-745,870 TRIHYDROCHLORIDE | | Synonyms: | L-745,870 TRIHYDROCHLORIDE;3HCl;3-(4-[4-CHLOROPHENYL]PIPERAZIN-1-YL)-METHYL-1H-PYRROLO[2,3-B]PYRIDINE TRIHYDROCHLORIDE;L 745870;3-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-;L-745,870 trihydroch;L 745870,L745870 | | CAS: | 158985-00-3 | | MF: | C18H19ClN4 | | MW: | 326.82 | | EINECS: | | | Product Categories: | | | Mol File: | 158985-00-3.mol |  |
| | L-745,870 TRIHYDROCHLORIDE Chemical Properties |
| Boiling point | 571.4±50.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO:16.5(Max Conc. mg/mL);50.49(Max Conc. mM) | | pka | 8.20±0.20(Predicted) |
| | L-745,870 TRIHYDROCHLORIDE Usage And Synthesis |
| Uses | L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials. | | Definition | ChEBI: 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine is a member of piperazines. | | Biological Activity | A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors. |
| | L-745,870 TRIHYDROCHLORIDE Preparation Products And Raw materials |
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