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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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Product Name:AZ 10417808;2-[(3,4-Dichlorophenyl)aMino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxaMide
CAS:331645-84-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:AZ 10417808
CAS:331645-84-2
Purity:98% by HPLC Remarks:AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells.
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| Company Name: |
AdooQ BioScience, LLC
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+1 (866) 930-6790 |
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info@adooq.com |
| Products Intro: |
Product Name:AZ 10417808
CAS:331645-84-2
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
EMMX Biotechnology LLC
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888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:AZ 10417808
CAS:331645-84-2
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Basic information |
| | 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Chemical Properties |
| storage temp. | Store at RT | | solubility | <10.86mg/ml in DMSO | | form | solid | | color | Yellow |
| | 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Usage And Synthesis |
| Uses | AZ 10417808 inhibits human caspase-3 with Ki values in the 90 to 800 nM range. AZ 10417808 blocks cellular and biochemical features of apoptosis in cells. | | Definition | ChEBI: 2-(3,4-dichloroanilino)-6-nitro-4-oxo-N-prop-2-enyl-1H-quinazoline-8-carboxamide is a member of quinazolines. | | Biological Activity | Selective non-peptide inhibitor of caspase-3 (K i = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (K i > 10 μ M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC 50 = 14.9 μ M). |
| | 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Preparation Products And Raw materials |
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