异丙地尔
| 中文名称 | 异丙地尔 |
|---|---|
| 中文同义词 | 异丙地尔;化合物 T13588 |
| 英文名称 | ipramidil |
| 英文同义词 | ipramidil;3,4-Bis[(isopropylamino)carbonyl]-1,2,5-oxadiazole 2-oxide;N,N'-Bis(1-methylethyl)furazan-3,4-dicarboxamide 2-oxide;C80-1324;1,2,5-Oxadiazole-3,4-dicarboxamide, N3,N4-bis(1-methylethyl)-, 2-oxide |
| CAS号 | 83656-38-6 |
| 分子式 | C10H16N4O4 |
| 分子量 | 256.26 |
| EINECS号 | 2805115 |
| 相关类别 | |
| Mol文件 | 83656-38-6.mol |
| 结构式 |  |
异丙地尔 性质
| 密度 | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.92±0.46(Predicted) |
The vasodilator action of Ipramidil (C80-1324) on coronary vessels is more potent than that of GTN and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by glyceryl trinitrate (GTN) is blunted upon coinfusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL,which induces an increase in coronary flow of 67±9% (N=5). Moreover, the vasodilatoreffect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance (P=0.493, N=3). However,when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished (P=0.006, N=3). Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect.