BVT 2733
| 中文名称 | BVT 2733 |
|---|---|
| 中文同义词 | 3-氯-2-甲基-N-(4-(2-(4-甲基哌嗪-1-基)-2-氧代乙基)噻唑-2-基)苯磺酰胺;化合物BVT 2733 |
| 英文名称 | BVT 2733 |
| 英文同义词 | 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;BVT 2733(BVT.2733);BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-;3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE;BVT2733, >98%;BVT.2733 >=98% (HPLC);HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity |
| CAS号 | 376640-41-4 |
| 分子式 | C17H21ClN4O3S2 |
| 分子量 | 428.96 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;Inhibitors |
| Mol文件 | 376640-41-4.mol |
| 结构式 |  |
BVT 2733 性质
| 沸点 | 636.9±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.427±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO 中≥42.9 mg/mL；不溶于水；不溶于乙醇 |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.36±0.10(Predicted) |
| Target | Value |
|
11β-HSD1
() |
BVT 2733 (100 μM; 24 hours) co-treatment with PA (100 µM) reduces MCP-1 expression in fully differentiation adipocytes.BVT 2733 (50-100 μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages by Elisa.
RT-PCR
| Cell Line: | Differentiation adipocytes |
| Concentration: | 100 μM |
| Incubation Time: | 24 hours |
| Result: | Down-regulated MCP-1 mRNA level. |
BVT-2733 (oral administration; 100 mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice.BVT 2733 (oral administration; 100 mg/kg; dosed (09.00 and 17.00 h); last 4 weeks) exhibits decreased body weight and enhanced glucose tolerance and insulin sensitivity when it compares to control mice. It also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo.
| Animal Model: | Collagen-induced arthritis (CIA) mice |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; twice daily; 2 weeks |
| Result: | Reduced synovial inflammation and joint destruction. |
| Animal Model: | C57BL/6J mice |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; dosed (09.00 and 17.00 h); last 4 weeks |
| Result: | Improved metabolic homeostasis and suppressed the inflammation of adipose tissue in diet-induced obese mice. |
安全信息
| 海关编码 | 2935909099 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S0209 | BVT 2733 BVT 2733 | 376640-41-4 | 5mg | 657.46元 |
| 2024/04/30 | S0209 | BVT 2733 BVT 2733 | 376640-41-4 | 25mg | 2383.47元 |