Methotrexate α-tert-Butyl Ester
| 中文名称 | Methotrexate α-tert-Butyl Ester |
|---|---|
| 中文同义词 | 187819 |
| 英文名称 | Methotrexate α-tert-Butyl Ester |
| 英文同义词 | Methotrexate α-tert-Butyl Ester;(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid;L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester;Methotrexate a-tert-Butyl Ester;Methotrexate α-tert-Butyl Ester;Methotrexate Impurity 8 |
| CAS号 | 79640-70-3 |
| 分子式 | C24H30N8O5 |
| 分子量 | 510.55 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 79640-70-3.mol |
| 结构式 |  |
Methotrexate α-tert-Butyl Ester 性质
| 熔点 | >211°C (dec.) |
|---|---|
| 密度 | 1.377±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于水基（轻微）、DMSO（轻微）、甲醇（轻微、加热） |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.43±0.10(Predicted) |
| 颜色 | 淡黄色至橙色 |
Methotrexate α-tert-butyl ester，经 OtBu 修饰，显著降低 HT1080 荷瘤小鼠的肿瘤生长。Methotrexate 是一种抗代谢和抗叶叶酸剂，也是一种免疫抑制剂和抗肿瘤药物。
OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity.
Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice.
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo.
| Animal Model: | Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells) |
| Dosage: | 30 mg/kg |
| Administration: | Once per week for 2 weeks |
| Result: | Showed a significant (63%) reduction in tumor size on day 12. |