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| | 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Basic information |
| Product Name: | 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER | | Synonyms: | Ethyl 2-chloro-2-(hydroxyimino)acetate 97%;(2Z)-2-chloro-2-hydroximino-acetic acid ethyl ester;(2Z)-2-chloro-2-hydroxyiminoacetic acid ethyl ester;ETHYLCHLOROXIMIDOACETATE;Ethyl 2-chloro-2-(hydroxyimino)ethanoate;2-chloro-2-hydroximino-acetic acid ethyl ester;ethyl (2Z)-2-chloro-2-hydroxyiminoacetate;ethyl (2Z)-2-chloro-2-hydroxyimino-acetate | | CAS: | 14337-43-0 | | MF: | C4H6ClNO3 | | MW: | 151.55 | | EINECS: | 604-347-4 | | Product Categories: | API;Acids and Derivatives | | Mol File: | 14337-43-0.mol |  |
| | 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Chemical Properties |
| Melting point | 70-76 °C (lit.) | | Boiling point | 230.5±23.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 7.60±0.10(Predicted) | | color | White to Almost white | | Sensitive | Moisture Sensitive/Lachrymatory | | BRN | 606193 | | CAS DataBase Reference | 14337-43-0(CAS DataBase Reference) |
| | 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Usage And Synthesis |
| Chemical Properties | off-white solid | | Uses | Ethyl 2-chloro-2-(hydroxyimino)acetate has been used:
- in the preparation of (+)-and (?)-Δ2-isoxazolines
- in the synthesis of CIP-AS (?), a chiral amino acid structurally related to glutamic acid, potential agonist at the ionotropic (±±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptors
- to generate ethoxycarbonylformonitrile oxide, in situ by treatment with sodium bicarbonate
- to prepare N-azirdinyloximes which on treatment with scandium triflate (418218) provide dihydro-oxadiazines
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| | 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER Preparation Products And Raw materials |
| Raw materials | Carbonocyanidic acid, ethyl ester, N-oxide-->Acetic acid, 2-(hydroxyimino)-, ethyl ester, (2E)--->ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE-->Ethyl 2-chloroacetoacetate-->Isoamyl nitrite-->ethyl glycinate-->Glycine ethyl ester hydrochloride-->Ethyl nitroacetate-->Sodium bicarbonate | | Preparation Products | Acetic acid, 2-chloro-2-nitro-, ethyl ester-->ETHYL 5-TRIBUTYLSTANNANYLISOXAZOLE-3-CARBOXYLATE-->ETHYL 5-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLATE-->3-(ethoxycarbonyl)-1,2-oxazole-5-carboxylic acid-->3-Isoxazolecarboxylic acid, 5-ethoxy-4,5-dihydro-, ethyl ester-->ethyl 5-pyridin-2-yl-4,5-dihydroisoxazole-3-carboxylate |
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